Pharmacology and Therapeutics of Asthma and COPD (Handbook of Experimental Pharmacology)

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Not in United States? Choose your country's store to see books available for purchase. See if you have enough points for this item. Sign in. The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the advances in our understanding of the pathogenesis and treatment of these diseases, including the substantial advances in the topical delivery of inhaled medicines.

Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of respiratory medicine. Textbook of Nephro-Endocrinology. Gordon H. Bone Cancer. Elsevier Science. Williams Hematology, 9E. Kenneth Kaushansky. William H. David G. Hematologic Malignancies. Bouthaina Dabaja. Hemostasis and Thrombosis. Victor J. Alan D. Clinical Malignant Hematology. Mikkael A.

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Lynette Fernandes

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Kanehisa, M. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. Dennis, G. Genome Biol. Bindea, G. ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics 25 , — Download references. All authors reviewed full-text manuscript for final revisions. Correspondence to Hong-Li Jiang. Reprints and Permissions.

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Advanced search. Skip to main content. Subjects Chronic obstructive pulmonary disease Clinical pharmacology. Introduction Chronic obstructive pulmonary disease COPD is a common preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation 1.

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Table 1 Herbal components of Yihuo Huatan Formula. Full size table. Figure 1. Full size image. Figure 2. Figure 3. Figure 4. Figure 5. Discussion Adopting the systems pharmacology-based methods, we generally uncovered the working mechanism of YHF for stable COPD by exploring the crucial active compounds, targets and pathways Fig. Figure 6. Conclusions In conclusion, we provided systems pharmacology-based means to gain insights into the working mechanism of YHF for COPD by dissecting the bioactive compounds, potential targets and compounds-targets-diseases networks.

Active ingredients prediction In order to make the best use of high cost and time-consuming biological experiments and clinical research, the previous prediction to discover the potential active natural products from CHM formula is very necessary. Specifically, a combination of OB screening and DL property evaluation was applied to explore the active substance of YHF 38 Oral bioavailability calculation OB refers to the relative amount of the drug taken into the systemic circulation after extravascular administration Drug-Likeness calculation DL index refers to the structural similarity of the herbal ingredients to a known drug.

Data Availability Related materials and data included in our study are from open database resources which are available to public. References 1. Article Google Scholar 4. Article Google Scholar 5.